“I-Baking Soda (i-Sodium Bicarbonate) engenabungozi nengenabungozi igqunywe kwi-nano 'capsule' ekhuselekileyo (i-liposome), kwaye i-tetracycline enamandla okubopha amathambo ifakwe phezu komphezulu ukuze inamathele kumphezulu wethambo. Xa ii-osteoclast zitshabalalisa izicubu zethambo ngokukhupha i-asidi, zinokukhupha i-Sodium Bicarbonate ngoko nangoko, zithintele ukusebenza kwee-osteoclasts kwaye zifezekise injongo yokuthintela i-osteoporosis ngokusisiseko.” Iqela elikhokelwa nguNjingalwazi uShunwu Fan weSebe leeOrthopedics, iRun Run Shaw Hospital, iYunivesithi yaseZhejiang, kunye noNjingalwazi uRuikang Tang weSebe leeKhemistri, kwiYunivesithi yaseZhejiang, kutshanje bapapashe iziphumo zabo kwiJenali ye-American Chemical Society.
Ngokwentshayelelo, ii-osteoclast zifana nee-termites emthini, xa sele zisebenza, kwanomthi omde, kodwa ngenxa yokubola nokuwa kwexesha elide. Izifundo zangoku zikholelwa ukuba imbangela ephambili ye-osteoporosis kukusebenza okungaqhelekanga kwee-osteoclasts, kwaye ukukhutshwa kwe-asidi yi-osteoclasts kuthathwa njengeyona nto iphambili yokutshatyalaliswa kwamathambo yi-osteoclasts kunye nemfuneko efunekayo yokonakala kwezicubu zamathambo.
Amayeza aphambili kunyango lwe-osteoporosis afezekisa injongo yokufunxwa kwamathambo kunye nokukhuthaza i-bone anabolism ngokugxila ekulawuleni i-osteoclast okanye i-osteoblast biology, kodwa awabulali inyathelo lokuqala eliphambili le-acid yangaphandle yokwakheka kwe-osteoclast ukusuka kumthombo. Ke ngoko, amayeza akhoyo anokunciphisa ukulahleka kwamathambo kubantu abadala ukuya kwinqanaba elithile, kodwa adla ngokungakwazi ukuguqula ngokupheleleyo ukutshatyalaliswa kwamathambo okwenzekileyo, kwaye ukulawulwa okukhethekileyo kwamayeza angengomathambo kunokukhokelela kwimiphumo emibi engeyiyo ejoliswe kuyo kunye neminye imiphumo emibi yamalungu omzimba.
Ukongeza, nangona ii-osteoclasts ziyimbangela ye-osteoporosis, izifundo ezininzi zibonise ukuba zidlala indima ekukhuthazeni ukwakheka kwamathambo kunye ne-angiogenesis njengee-"precursor cells" ngaphambi kokuba zikhuphe i-asidi. Ke ngoko, kubaluleke kakhulu ukuthintela ngokuchanekileyo ii-osteoclasts.
Iqela likaFan Shunwu kunye neqela likaTang Ruikang baqalise ukujolisa ii-liposomes zeSodium Bicarbonate kumphezulu wethambo, benza umaleko okhuselayo we-alkaline, banciphisa i-asidi ekhutshwa zii-osteoclasts, bathintela ukusebenza okungaqhelekanga kwee-osteoclasts, kwaye baphinda babumbe ibhalansi yendalo yamathambo ukuze kufezekiswe isiphumo sokunyanga i-osteoporosis.
ULin Xianfeng, ugqirha wamathambo kwiSibhedlele iRun Run Shaw kwiYunivesithi yaseZhejiang, uthe olu phononongo lufumanise ukuba izinto ze-alkaline liposome kunye nendawo ene-asidi yengingqi ye-osteoclasts zibangele inani elikhulu le-apoptosis ye-osteoclasts, kwaye zikhuphe inani elikhulu le-extracellular vesicles. "Kufana neseti yeedominoes, ezityhalelwa umaleko omnye ngexesha kwaye zandiswe inyathelo elinye ngexesha ukuze zimelane ngokupheleleyo nokutshatyalaliswa kwamathambo okubangelwa kukuqina kwee-osteoclasts."
Ixesha lokuposa: Jan-27-2021