"I-Baking Soda engeyiyo inetyhefu kwaye ingenabungozi (iSodium Bicarbonate) ifakwe ngaphakathi kwi-nano 'capsule' ekhuselekileyo (liposome), kunye ne-tetracycline enamandla okubopha amathambo ibekwe kumphezulu ukuze ithengise umphezulu wethambo. Xa ii-osteoclast zitshabalalisa ithambo ngokufihla iasidi, banokukhupha iSodium Bicarbonate ngoko nangoko, kuthintele ukusebenza kwamathambo kunye nokufezekisa injongo yokuthintela i-osteoporosis. ” Iqela elikhokelwe nguNjingalwazi Shunwu Fan weSebe le-Orthopedics, i-Run Run Shaw Hospital, iYunivesithi yaseZhejiang, kunye noNjingalwazi Ruikang Tang weSebe leKhemistry, kwiYunivesithi yaseZhejiang, kutshanje bapapashe iziphumo zabo kwiJenali yeAmerican Chemical Society.
Ngokwentshayelelo, ii-osteoclasts zifana neentubi emthini, xa sele zisebenza, nokuba ngumthi omde, kodwa nangenxa yokubola nokuwa kwexesha elide. Izifundo ezikhoyo ngoku zikholelwa ekubeni oyena nobangela we-osteoporosis kukusebenza ngokungaqhelekanga kwamathambo, kunye nokufihlwa kwe-asidi ngama-osteoclast kuthathwa njengeyona nto iphambili ekutshatyalalisweni kwethambo ngama-osteoclast kunye nemfuneko eyimfuneko yokonakaliswa kwamathambo.
Amachiza aphambili kunyango lwe-osteoporosis afezekisa injongo ye-anti-bone resorption kunye nokukhuthaza i-bone anabolism ngokugxila kummiselo we-osteoclast okanye i-osteoblast biology, kodwa ayibulali inyathelo lokuqala le-asidi yendawo ye-osteoclast form evela imvelaphi. Ke ngoko, amachiza akhoyo anokucothisa ukulahleka kwamathambo kubantu abadala ukuya kwinqanaba elithile, kodwa amaxesha amaninzi akanakukuguqula ngokupheleleyo ukutshatyalaliswa kwethambo okwenzekileyo, kunye nolawulo olukhethiweyo lweziyobisi ezingezizo ezamathambo kunokukhokelela ekujoliseni nasekujoliseni ezinye iziphumo ebezingalindelekanga zamalungu.
Ukongeza, nangona ii-osteoclast zingunobangela we-osteoporosis, uninzi lwezifundo lubonakalisile ukuba badlala indima ekukhuthazeni ukwakheka kwamathambo kunye ne-angiogenesis njenge "iiseli zangaphambili" ngaphambi kokufihla i-asidi. Ke ngoko, kubaluleke kakhulu ukuthintela i-osteoclast ngokuchanekileyo.
Iqela likaFan Shunwu kunye neqela likaTang Ruikang baba nguvulandlela ekujoliseni i-Sodium Bicarbonate liposomes kumhlaba wethambo, besenza umaleko okhusela i-alkaline, ithomalalisa i-asidi egcinwe zii-osteoclast, ukuthintela ukwenziwa okungaqhelekanga kwe-osteoclast, kunye nokubuyisela ibhalansi yethambo le-microenvelo ukuze liphumeze unyango lwe-osteoporosis .
U-Lin Xianfeng, ugqirha wamathambo e-Run Run Shaw Hospital yeYunivesithi yase Zhejiang, uthe uphononongo lufumanise ukuba izinto ze-alkaline liposome kunye nendawo ye-asidi yendawo ye-osteoclast ibangele inani elikhulu le-apoptosis ye-osteoclasts, kwaye ikhuphe inani elikhulu lee-vesicle zangaphandle. "Ifana neqela leedomino, ezityhalwa zangumaleko omnye ngexesha kwaye inyusa inyathelo elinye ngexesha ukumelana ngokupheleleyo nokutshatyalaliswa kwamathambo okubangelwe kukomeleza kwamathambo."
Ixesha Post: Jan-27-2021